Author(s)
Alessandra Jin, MD
Gustavo Leao Castilho, MD
Silke Anna Theresa Weber
Marcia Guimarães, MD
Jefferson L. Barros, MD
Affiliation(s)
Faculdade de Medicina de Botucatu UNESP
Abstract:
Keywords: Obstructive sleep apnea, CPAP, inflammatory profile, oxidative stress.Objective: To evaluate the inflammatory profile in obstructive sleep apnea (OSA) patients treated with CPAP for a short period. Methods: A randomized double-blind clinical trial with Committee of Ethics in Research approval (CAAE: 20839713.3.0000.5411). January 2013 to january 2015. 60 Medical School UNESP male and female adults patients with polysomnographic diagnosis of OSAS were distributed into two groups: Group I= patients using CPAP at minimum pressure of 4 cmH2O (n=30) and Group II= patients utilizing CPAP at the ideal therapeutic pressure (n=30). All patients used CPAP for one week. The dose of interleukin- (IL-6), interleukin-10 (IL-10) cytokines, tumor necrosis factor-α (TNF- α), Hydrophilic Antioxidant Capacity (HAC) and Malonildialdehid (MDA) was determined in serum. Both groups were evaluated before and after the intervention.Results: 38 patients participated, (24 males) and showed homogeneity between both groups for sex, age, BMI, HAI, IL-6, IL-10, TNF-α, HAC and MDA at first analysis. No significant difference was observed for IL-6, IL-10, TNF-α and MDA for comparison of the groups after CPAP intervention. A significant increase was verified for HAC in Group I and there was an increase tendency for HAC in Group II.Conclusion: The inflammatoryprofile and oxidative stress level did not vary with CPAP utilization for one week; however, the following were observed: significant increase in HAC after utilizing CPAP at minimum pressure of 4cmH2O, and tendency to increase HAC in patients using therapeutic CPAP.