Author(s)
Krupal Patel, MD
Brian Rotenberg, MD, MPH
Doron Sommer, MD
Leigh Sowerby, MD, MHM
Affiliation(s)
Western University
Abstract:
"Objective:
Aspirin Exacerbated Respiratory Disease (AERD) has classic triad of chronic rhinosinusitis due to nasal polyposis, asthma and intolerance to aspirin and other NSAIDs. Our objective was to assess if low salicylate diet would result in symptomatic improvement and decrease in inflammatory markers.
Study Design:
Study design included randomization to either a high or low salicylate diet for the first week, followed by cross-over to the other arm. Patient’s were asked to record their dietary salicylate for each week of the study. SNOT-22 questionnaire was filled out at baseline, end of week one and end of week 2. Urine was collected and urinary creatinine, leukotrienes and salicylate levels were measured at the time of recruitment, end of week one and end of week two.
Results:
Total of seven patient were recruited. Patients reported improved symptoms on low salicylate diet on the SNOT-22 scales for the following symptoms (all p < 0.05): ""need to blow nose"", ""sneezing"", ""thick nasal discharge"", ""ear fullness"", ""facial pain/pressure"", ""wake up tired"", ""reduced productivity"", and ""nasal blockage"". There was no statistical difference observed between urinary leukotrienes levels between two diets.
Conclusion:
Patients with AERD should be counseled on low salicylate diet to provide symptomatic relief. No difference was observed in urinary leukotriene levels."