Author(s)
Hassan Nasser, MD
Edward Kuan, MD
Jose Alonso, BS
Bobby Tajudeen, MD
Marilene Wang, MD
Maie St. John, MD, PhD
Affiliation(s)
UCLA
Abstract:
INTRODUCTION: Esthesioneuroblastoma is an uncommon malignancy of the sinonasal tract arising from the olfactory epithelium. Surgical management of the primary site, often via an endoscopic approach, with or without adjuvant radiation, is often curative. There is limited data regarding management of the neck and the risk of nodal metastases. In this study, we examine the incidence and patterns of esthesioneuroblastoma-related cervical nodal metastases using the Surveillance, Epidemiology, and End Results (SEER) database.METHODS: The SEER registry was queried for all patients with esthesioneuroblastomas diagnosed between 1973 and 2012. Patient data was then analyzed with respect to age, sex, race, modified Kadish stage, grade, survival functions, and nodal disease, including specific nodal basins.RESULTS: 381 cases of esthesioneuroblastoma with information on nodal metastases were identified. The overall cervical nodal metastasis rate was 8.7%. Level II metastases were most common (6.6%). 4.5% of cases presented with multiple positive nodal basins. Male sex (p=0.009) and higher tumor grade (p=0.009) correlated with the presence of level II metastases. There was no association of primary tumor site to the presence of nodal metastases (p>0.05). The presence of nodal disease significantly predicted poorer overall (p=0.001) and disease-specific survival (p=0.017).CONCLUSIONS: The incidence of nodal metastases in esthesioneuroblastoma at diagnosis is rare, and elective management of the neck remains controversial. Primary tumor site does not appear to predict metastases at specific nodal basins.