Author(s)
Janet O Adeola, MS
Jimmy S Patel, PhD
Roman Povolotskiy, MD
Jordon G Grube, DO
Wayne D Hsueh, MD
Soly Baredes, MD
Jean Anderson Eloy, MD
Affiliation(s)
Rutgers New Jersey Medical School;
Abstract:
Objective: Laryngeal Chondrosarcoma is a rare malignancy with a handful of studies documenting its clinicopathologic characteristics and treatment options. This study reports the prevalence, demographics, and treatment modalities that influence survival rates for this rare tumor.
Method: The National Cancer Database (NCDB) was queried for cases of Laryngeal Chondrosarcoma reported from 2004-2016. 274 cases that met inclusion criteria were analyzed for demographic and clinicopathologic characteristics. Kaplan- Meier (KM) and Cox proportional hazard analysis were conducted to identify variables that impacted the survival of patients.
Results: Laryngeal Chondrosarcoma was found to be more common in males (74.8%) and in white patients (92.3%). The mean age of patients was 61.8 years (± SD 11.6) with the most common primary site being laryngeal cartilage (70.8%). 72.6% of patients were treated with surgery, most commonly: partial laryngectomy (31.4%), total laryngectomy (25.5%), and local excision (22.3%). 88.3% of patients had no evidence of nodal disease and 85.9% of patients did not have metastasis at presentation. KM analysis revealed a 5-year overall survival (5YOS) of 89.0%. Age, insurance status, facility type and surgery type were significant predictors of 5YOS on KM analysis (p<0.05). On Cox Proportional Hazard analysis private insurance significantly improved survival (HR 0.21; p=0.048). However, increasing age was a poor prognostic indicator (HR 1.10; p=0.004).
Conclusion: Our results demonstrated that the type of surgery performed may not significantly impact survival. However, private insurance improved survival while increasing age was associated with an increased hazard of death.