Author(s)
Robert E. Africa, MD
Amber M. Dunmire, MD
Shahruhk R. Ali
Brian J. McKinnon, MD MPH MBA
Charles A. Hughes, MD MPH MBA
Scott A. Hardison, MD
Affiliation(s)
University of Texas Medical Branch
Abstract:
Educational Objective: At the conclusion of this presentation, participants should understand the epidemiological association between chronic rhinosinusitis (CRS) with premorbid autoimmune diseases. Participants will additionally recognize the association between CRS with nasal polyposis and other autoimmune disease that have not been previously evaluated including gastrointestinal and dermatological.
Objectives: To evaluate the epidemiological associations between CRS with or without nasal polyposis and a wide variety of autoimmune diseases with a large population-based database. The present study will be the largest known study with other autoimmune disease that have not been previously well studied.
Study Design: Multicenter retrospective cohort study utilizing de-identified patient data from the United States.
Methods: The TriNetX database was utilized to identify patients with or without autoimmune diseases including alopecia areata, ankylosing spondylitis, celiac disease, Crohn's disease, dermatomyositis, fibromyalgia, granulomatosis with polyangiitis (GPA), Hashimoto's disease, multiple sclerosis, rheumatoid arthritis, ulcerative colitis, and systemic lupus erythematous (SLE) among many others. The rates of CRS with or without nasal polyposis were evaluated.
Results: Patients with alopecia areata, ankylosing spondylitis, celiac disease, Crohn’s disease, dermatomyositis, fibromyalgia, GPA, Hashimoto's disease, multiple sclerosis, rheumatoid arthritis, and ulcerative colitis had a significant association with CRS without nasal polyposis (RR 1.13[1.02-1.25]; 1.31[1.20-1.43]; 1.25[1.18-1.33]; 1.19[1.13-1.26]; 1.16[1.02-1.32]; 1.28[1.25-1.30]; 1.71[1.60-1.84]; 1.12[1.08-1.17]; 1.12[1.06-1.19]; 1.31[1.27-1.35]; 1.20[1.14-1.26]). GPA, fibromyalgia, Hashimoto's disease, multiple sclerosis, and ulcerative colitis were significantly associated with CRS with nasal polyposis (RR 1.18[1.10-1.26]; 1.05[1.02-1.07]; 1.06[1.02-1.11]; 1.20[1.02-1.18]; 1.11[1.06-1.17]).
Conclusions: In a large national database, there are multiple significant associations between a wide variety of autoimmune diseases and development of CRS but fewer epidemiological associations with development of CRS with nasal polyposis.